# Sequence dependent interactions between Nucleic Acids ## expand\_more The sequence dependent pairing of ssDNA with ssDNA is well known; however, the Prentiss group has shown that dsDNA-dsDNA pairing can also be sequence dependent. ![Pairing of homologous DNAs using the parallel single molecule, magnetic tweezers-based assay.](/sites/g/files/omnuum7031/files/styles/hwp_1_1__360x360_scale/public/prentiss/files/sequence_dependent_interactions_1.jpg?itok=xS_lSMSo) *Pairing of homologous DNAs using the parallel single molecule, magnetic tweezers-based assay.* ![Effect of sequence on DNA pairing.](/sites/g/files/omnuum7031/files/styles/hwp_1_1__360x360_scale/public/prentiss/files/sequence_dependent_interactions_2.png?itok=4O-6EvJ5) *Effect of sequence on DNA pairing.* In addition, the stringency of the pairing between long ssDNA molecules can be enhanced by inserted abasic sites into one of the ssDNA strands. [ssDNA Pairing Accuracy Increases When Abasic Sites Divide Nucleotides into Small Groups (plos.org)](https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0130875) ![Measurements of the melting temperature, Tm.](/sites/g/files/omnuum7031/files/styles/hwp_1_1__360x360_scale/public/prentiss/files/sequence_dependent_interactions_3.png?itok=yHWLUQ4-) *Measurements of the melting temperature, Tm.*Finally, sequence dependent interactions between ssDNA and dsDNA can bring dsDNA molecules together --- Attachments- [ image sequence\_dependent\_interactions\_1.jpg ](/sites/g/files/omnuum7031/files/prentiss/files/sequence_dependent_interactions_1.jpg) - [ image sequence\_dependent\_interactions\_2.png ](/sites/g/files/omnuum7031/files/prentiss/files/sequence_dependent_interactions_2.png) - [ image sequence\_dependent\_interactions\_3.png ](/sites/g/files/omnuum7031/files/prentiss/files/sequence_dependent_interactions_3.png) ---